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Additionally, GLP-1 receptor activation influences intestinal motility and fluid secretion, which may contribute to changes in stool consistency and frequency, including diarrhea (defined as three or more loose or watery stools per day)

Eli Lilly states it must be discarded if frozen, even after thawing

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Research has shown that this stimulation occurs in a pulsatile and time-dependent manner, closely aligning with naturally observed secretion rhythms studied in endocrine models